HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in colorectal cancer. Therefore, here we explored a...

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Bibliographic Details
Main Authors: Zhang, Wenjing, Shi, Xinpeng, Peng, Ying, Wu, Meiyan, Zhang, Pei, Xie, Ruyi, Wu, Yao, Yan, Qingqing, Liu, Side, Wang, Jide
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461314/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461314/

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