Therapeutic potential of mGluR5 targeting in Alzheimer's disease
Decades of research dedicated toward Alzheimer's disease (AD) has culminated in much of the current understanding of the neurodegeneration associated with disease. However, delineating the pathophysiology and finding a possible cure for the disease is still wanting. This is in part due to the l...
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Frontiers Media S.A.
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460345/ |
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pubmed-44603452015-06-23 Therapeutic potential of mGluR5 targeting in Alzheimer's disease Kumar, Anil Dhull, Dinesh K. Mishra, Pooja S. Pharmacology Decades of research dedicated toward Alzheimer's disease (AD) has culminated in much of the current understanding of the neurodegeneration associated with disease. However, delineating the pathophysiology and finding a possible cure for the disease is still wanting. This is in part due to the lack of knowledge pertaining to the connecting link between neurodegenerative and neuroinflammatory pathways. Consequently, the inefficacy and ill-effects of the drugs currently available for AD encourage the need for alternative and safe therapeutic intervention. In this review we highlight the potential of mGluR5, a metabotropic glutamatergic receptor, in understanding the mechanism underlying the neuronal death and neuroinflammation in AD. We also discuss the role of mGlu5 receptor in mediating the neuron-glia interaction in the disease. Finally, we discuss the potential of mGluR5 as target for treating AD. Frontiers Media S.A. 2015-06-09 /pmc/articles/PMC4460345/ /pubmed/26106290 http://dx.doi.org/10.3389/fnins.2015.00215 Text en Copyright © 2015 Kumar, Dhull and Mishra. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kumar, Anil Dhull, Dinesh K. Mishra, Pooja S. |
| spellingShingle |
Kumar, Anil Dhull, Dinesh K. Mishra, Pooja S. Therapeutic potential of mGluR5 targeting in Alzheimer's disease |
| author_facet |
Kumar, Anil Dhull, Dinesh K. Mishra, Pooja S. |
| author_sort |
Kumar, Anil |
| title |
Therapeutic potential of mGluR5 targeting in Alzheimer's disease |
| title_short |
Therapeutic potential of mGluR5 targeting in Alzheimer's disease |
| title_full |
Therapeutic potential of mGluR5 targeting in Alzheimer's disease |
| title_fullStr |
Therapeutic potential of mGluR5 targeting in Alzheimer's disease |
| title_full_unstemmed |
Therapeutic potential of mGluR5 targeting in Alzheimer's disease |
| title_sort |
therapeutic potential of mglur5 targeting in alzheimer's disease |
| description |
Decades of research dedicated toward Alzheimer's disease (AD) has culminated in much of the current understanding of the neurodegeneration associated with disease. However, delineating the pathophysiology and finding a possible cure for the disease is still wanting. This is in part due to the lack of knowledge pertaining to the connecting link between neurodegenerative and neuroinflammatory pathways. Consequently, the inefficacy and ill-effects of the drugs currently available for AD encourage the need for alternative and safe therapeutic intervention. In this review we highlight the potential of mGluR5, a metabotropic glutamatergic receptor, in understanding the mechanism underlying the neuronal death and neuroinflammation in AD. We also discuss the role of mGlu5 receptor in mediating the neuron-glia interaction in the disease. Finally, we discuss the potential of mGluR5 as target for treating AD. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460345/ |
| _version_ |
1613233319225327616 |