Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane

Data from a new in vitro assay measuring inner nuclear membrane (INM) targeting kinetics as well as from mathematical modeling support a diffusion-retention–based mechanism of INM targeting.

Bibliographic Details
Main Authors: Ungricht, Rosemarie, Klann, Michael, Horvath, Peter, Kutay, Ulrike
Format: Online
Language:English
Published: The Rockefeller University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460150/