First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain
We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistan...
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| Format: | Online |
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Elsevier
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459865/ |
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pubmed-44598652015-06-16 First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain Pelaez, T. Monteiro, M.C. Garcia-Rubio, R. Bouza, E. Gomez-Lopez, A. Mellado, E. First Clinical Case Report We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance. Elsevier 2015-04-20 /pmc/articles/PMC4459865/ /pubmed/26082842 http://dx.doi.org/10.1016/j.nmni.2015.04.005 Text en © 2015 The Authors |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Pelaez, T. Monteiro, M.C. Garcia-Rubio, R. Bouza, E. Gomez-Lopez, A. Mellado, E. |
| spellingShingle |
Pelaez, T. Monteiro, M.C. Garcia-Rubio, R. Bouza, E. Gomez-Lopez, A. Mellado, E. First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain |
| author_facet |
Pelaez, T. Monteiro, M.C. Garcia-Rubio, R. Bouza, E. Gomez-Lopez, A. Mellado, E. |
| author_sort |
Pelaez, T. |
| title |
First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain |
| title_short |
First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain |
| title_full |
First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain |
| title_fullStr |
First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain |
| title_full_unstemmed |
First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain |
| title_sort |
first detection of aspergillus fumigatus azole-resistant strain due to cyp51a tr46/y121f/t289a in an azole-naive patient in spain |
| description |
We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance. |
| publisher |
Elsevier |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459865/ |
| _version_ |
1613233096658780160 |