3D Printing of Octacalcium Phosphate Bone Substitutes

Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent...

Full description

Bibliographic Details
Main Authors:	Komlev, Vladimir S., Popov, Vladimir K., Mironov, Anton V., Fedotov, Alexander Yu., Teterina, Anastasia Yu., Smirnov, Igor V., Bozo, Ilya Y., Rybko, Vera A., Deev, Roman V.
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459096/

id	pubmed-4459096
recordtype	oai_dc
spelling	pubmed-44590962015-06-23 3D Printing of Octacalcium Phosphate Bone Substitutes Komlev, Vladimir S. Popov, Vladimir K. Mironov, Anton V. Fedotov, Alexander Yu. Teterina, Anastasia Yu. Smirnov, Igor V. Bozo, Ilya Y. Rybko, Vera A. Deev, Roman V. Bioengineering and Biotechnology Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent approach to overcome the limitation supporting effective and fast fabrication of individual complex bone substitutes. Here, we proposed a relatively simple route for 3D printing of octacalcium phosphates (OCP) in complexly shaped structures by the combination of inkjet printing with post-treatment methodology. The printed OCP blocks were further implanted in the developed cranial bone defect followed by histological evaluation. The obtained result confirmed the potential of the developed OCP bone substitutes, which allowed 2.5-time reducing of defect’s diameter at 6.5 months in a region where native bone repair is extremely inefficient. Frontiers Media S.A. 2015-06-08 /pmc/articles/PMC4459096/ /pubmed/26106596 http://dx.doi.org/10.3389/fbioe.2015.00081 Text en Copyright © 2015 Komlev, Popov, Mironov, Fedotov, Teterina, Smirnov, Bozo, Rybko and Deev. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Komlev, Vladimir S. Popov, Vladimir K. Mironov, Anton V. Fedotov, Alexander Yu. Teterina, Anastasia Yu. Smirnov, Igor V. Bozo, Ilya Y. Rybko, Vera A. Deev, Roman V.
spellingShingle	Komlev, Vladimir S. Popov, Vladimir K. Mironov, Anton V. Fedotov, Alexander Yu. Teterina, Anastasia Yu. Smirnov, Igor V. Bozo, Ilya Y. Rybko, Vera A. Deev, Roman V. 3D Printing of Octacalcium Phosphate Bone Substitutes
author_facet	Komlev, Vladimir S. Popov, Vladimir K. Mironov, Anton V. Fedotov, Alexander Yu. Teterina, Anastasia Yu. Smirnov, Igor V. Bozo, Ilya Y. Rybko, Vera A. Deev, Roman V.
author_sort	Komlev, Vladimir S.
title	3D Printing of Octacalcium Phosphate Bone Substitutes
title_short	3D Printing of Octacalcium Phosphate Bone Substitutes
title_full	3D Printing of Octacalcium Phosphate Bone Substitutes
title_fullStr	3D Printing of Octacalcium Phosphate Bone Substitutes
title_full_unstemmed	3D Printing of Octacalcium Phosphate Bone Substitutes
title_sort	3d printing of octacalcium phosphate bone substitutes
description	Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent approach to overcome the limitation supporting effective and fast fabrication of individual complex bone substitutes. Here, we proposed a relatively simple route for 3D printing of octacalcium phosphates (OCP) in complexly shaped structures by the combination of inkjet printing with post-treatment methodology. The printed OCP blocks were further implanted in the developed cranial bone defect followed by histological evaluation. The obtained result confirmed the potential of the developed OCP bone substitutes, which allowed 2.5-time reducing of defect’s diameter at 6.5 months in a region where native bone repair is extremely inefficient.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459096/
_version_	1613232830616174592

3D Printing of Octacalcium Phosphate Bone Substitutes

Similar Items