Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report

Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report

•Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases.•PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA.•The genetic profile suggests that the carcin...

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Main Authors: Ikeda, Yuji, Oda, Katsutoshi, Aburatani, Hiroyuki, Kawana, Kei, Osuga, Yutaka, Fujii, Tomoyuki
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458747/
id pubmed-4458747
recordtype oai_dc
spelling pubmed-44587472015-06-16 Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report Ikeda, Yuji Oda, Katsutoshi Aburatani, Hiroyuki Kawana, Kei Osuga, Yutaka Fujii, Tomoyuki Case Report •Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases.•PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA.•The genetic profile suggests that the carcinogenesis of PVCCA might have elements common with that of OCCA. Elsevier 2014-06-05 /pmc/articles/PMC4458747/ /pubmed/26082939 http://dx.doi.org/10.1016/j.gynor.2014.05.006 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ikeda, Yuji
Oda, Katsutoshi
Aburatani, Hiroyuki
Kawana, Kei
Osuga, Yutaka
Fujii, Tomoyuki
spellingShingle Ikeda, Yuji
Oda, Katsutoshi
Aburatani, Hiroyuki
Kawana, Kei
Osuga, Yutaka
Fujii, Tomoyuki
Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
author_facet Ikeda, Yuji
Oda, Katsutoshi
Aburatani, Hiroyuki
Kawana, Kei
Osuga, Yutaka
Fujii, Tomoyuki
author_sort Ikeda, Yuji
title Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_short Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_full Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_fullStr Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_full_unstemmed Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_sort non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: a case report
description •Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases.•PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA.•The genetic profile suggests that the carcinogenesis of PVCCA might have elements common with that of OCCA.
publisher Elsevier
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458747/
_version_ 1613232707196682240

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