A framework for prescription in exercise-oncology research†

The field of exercise-oncology has increased dramatically over the past two decades, with close to 100 published studies investigating the efficacy of structured exercise training interventions in patients with cancer. Of interest, despite considerable differences in study population and primary stu...

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Main Authors:	Sasso, John P, Eves, Neil D, Christensen, Jesper F, Koelwyn, Graeme J, Scott, Jessica, Jones, Lee W
Format:	Online
Language:	English
Published:	BlackWell Publishing Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458077/

id	pubmed-4458077
recordtype	oai_dc
spelling	pubmed-44580772015-06-11 A framework for prescription in exercise-oncology research† Sasso, John P Eves, Neil D Christensen, Jesper F Koelwyn, Graeme J Scott, Jessica Jones, Lee W Editorials The field of exercise-oncology has increased dramatically over the past two decades, with close to 100 published studies investigating the efficacy of structured exercise training interventions in patients with cancer. Of interest, despite considerable differences in study population and primary study end point, the vast majority of studies have tested the efficacy of an exercise prescription that adhered to traditional guidelines consisting of either supervised or home-based endurance (aerobic) training or endurance training combined with resistance training, prescribed at a moderate intensity (50–75% of a predetermined physiological parameter, typically age-predicted heart rate maximum or reserve), for two to three sessions per week, for 10 to 60 min per exercise session, for 12 to 15 weeks. The use of generic exercise prescriptions may, however, be masking the full therapeutic potential of exercise treatment in the oncology setting. Against this background, this opinion paper provides an overview of the fundamental tenets of human exercise physiology known as the principles of training, with specific application of these principles in the design and conduct of clinical trials in exercise-oncology research. We contend that the application of these guidelines will ensure continued progress in the field while optimizing the safety and efficacy of exercise treatment following a cancer diagnosis. BlackWell Publishing Ltd 2015-06 2015-05-11 /pmc/articles/PMC4458077/ /pubmed/26136187 http://dx.doi.org/10.1002/jcsm.12042 Text en © 2015 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society of Sarcopenia, Cachexia and Wasting Disorders http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sasso, John P Eves, Neil D Christensen, Jesper F Koelwyn, Graeme J Scott, Jessica Jones, Lee W
spellingShingle	Sasso, John P Eves, Neil D Christensen, Jesper F Koelwyn, Graeme J Scott, Jessica Jones, Lee W A framework for prescription in exercise-oncology research†
author_facet	Sasso, John P Eves, Neil D Christensen, Jesper F Koelwyn, Graeme J Scott, Jessica Jones, Lee W
author_sort	Sasso, John P
title	A framework for prescription in exercise-oncology research†
title_short	A framework for prescription in exercise-oncology research†
title_full	A framework for prescription in exercise-oncology research†
title_fullStr	A framework for prescription in exercise-oncology research†
title_full_unstemmed	A framework for prescription in exercise-oncology research†
title_sort	framework for prescription in exercise-oncology research†
description	The field of exercise-oncology has increased dramatically over the past two decades, with close to 100 published studies investigating the efficacy of structured exercise training interventions in patients with cancer. Of interest, despite considerable differences in study population and primary study end point, the vast majority of studies have tested the efficacy of an exercise prescription that adhered to traditional guidelines consisting of either supervised or home-based endurance (aerobic) training or endurance training combined with resistance training, prescribed at a moderate intensity (50–75% of a predetermined physiological parameter, typically age-predicted heart rate maximum or reserve), for two to three sessions per week, for 10 to 60 min per exercise session, for 12 to 15 weeks. The use of generic exercise prescriptions may, however, be masking the full therapeutic potential of exercise treatment in the oncology setting. Against this background, this opinion paper provides an overview of the fundamental tenets of human exercise physiology known as the principles of training, with specific application of these principles in the design and conduct of clinical trials in exercise-oncology research. We contend that the application of these guidelines will ensure continued progress in the field while optimizing the safety and efficacy of exercise treatment following a cancer diagnosis.
publisher	BlackWell Publishing Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458077/
_version_	1613232548076322816

A framework for prescription in exercise-oncology research†

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