Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease

Mutations in the PARK2 gene are associated with an autosomal recessive form of juvenile parkinsonism (AR-JP). These mutations affect parkin solubility and impair its E3 ligase activity, leading to a toxic accumulation of proteins within susceptible neurons that results in a slow but progressive neur...

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Bibliographic Details
Main Authors: Romaní-Aumedes, J, Canal, M, Martín-Flores, N, Sun, X, Pérez-Fernández, V, Wewering, S, Fernández-Santiago, R, Ezquerra, M, Pont-Sunyer, C, Lafuente, A, Alberch, J, Luebbert, H, Tolosa, E, Levy, O A, Greene, L A, Malagelada, C
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454308/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454308/

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