Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal pathogen, and a worldwide public health burden. Most disease-causing strains secrete two exotoxins, TcdA and TcdB, which are considered to be the primary virulence factors. Understanding the role that th...

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Bibliographic Details
Main Authors: Carter, Glen P., Chakravorty, Anjana, Pham Nguyen, Tu Anh, Mileto, Steven, Schreiber, Fernanda, Li, Lucy, Howarth, Pauline, Clare, Simon, Cunningham, Bliss, Sambol, Susan P., Cheknis, Adam, Figueroa, Iris, Johnson, Stuart, Gerding, Dale, Rood, Julian I., Dougan, Gordon, Lawley, Trevor D., Lyras, Dena
Format: Online
Language:English
Published: American Society of Microbiology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453007/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453007/

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