Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells

Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells

Viruses can trigger apoptosis of infected host cells if not counteracted by cellular or viral anti-apoptotic proteins. These protective proteins either inhibit the activation of caspases or they act as Bcl-2 homologs to prevent Bax/Bak-mediated outer mitochondrial membrane permeabilization (MOMP). T...

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Bibliographic Details
Main Authors: Papaianni, Emanuela, El Maadidi, Souhayla, Schejtman, Andrea, Neumann, Simon, Maurer, Ulrich, Marino-Merlo, Francesca, Mastino, Antonio, Borner, Christoph
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452691/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452691/

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