Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder

Frontotemporal neural systems are highly implicated in the emotional dysregulation characteristic of bipolar disorder (BD). Convergent genetic, postmortem, behavioral and neuroimaging evidence suggests abnormalities in the development of frontotemporal white matter (WM) in the pathophysiology of BD....

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Main Authors:	de Zwarte, Sonja M. C., Johnston, Jennifer A. Y., Cox Lippard, Elizabeth T., Blumberg, Hilary P.
Format:	Online
Language:	English
Published:	MDPI 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449671/

id	pubmed-4449671
recordtype	oai_dc
spelling	pubmed-44496712015-07-28 Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder de Zwarte, Sonja M. C. Johnston, Jennifer A. Y. Cox Lippard, Elizabeth T. Blumberg, Hilary P. Review Frontotemporal neural systems are highly implicated in the emotional dysregulation characteristic of bipolar disorder (BD). Convergent genetic, postmortem, behavioral and neuroimaging evidence suggests abnormalities in the development of frontotemporal white matter (WM) in the pathophysiology of BD. This review discusses evidence for the involvement of abnormal WM development in BD during adolescence, with a focus on frontotemporal WM. Findings from diffusion tensor imaging (DTI) studies in adults and adolescents are reviewed to explore possible progressive WM abnormalities in the disorder. Intra- and interhemispheric frontotemporal abnormalities were reported in adults with BD. Although evidence in children and adolescents with BD to date has been limited, similar intrahemispheric and interhemispheric findings have also been reported. The findings in youths suggest that these abnormalities may represent a trait marker present early in the course of BD. Functional connectivity studies, demonstrating a relationship between WM abnormalities and frontotemporal dysfunction in BD, and DTI studies of vulnerability in first-degree relatives of individuals with BD, are discussed. Together, findings suggest the involvement of abnormal frontotemporal WM development in the pathophysiology of BD and that these abnormalities may be early trait markers of vulnerability; however, more studies are critically needed. MDPI 2014-03-10 /pmc/articles/PMC4449671/ /pubmed/26237259 http://dx.doi.org/10.3390/jcm3010233 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	de Zwarte, Sonja M. C. Johnston, Jennifer A. Y. Cox Lippard, Elizabeth T. Blumberg, Hilary P.
spellingShingle	de Zwarte, Sonja M. C. Johnston, Jennifer A. Y. Cox Lippard, Elizabeth T. Blumberg, Hilary P. Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder
author_facet	de Zwarte, Sonja M. C. Johnston, Jennifer A. Y. Cox Lippard, Elizabeth T. Blumberg, Hilary P.
author_sort	de Zwarte, Sonja M. C.
title	Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder
title_short	Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder
title_full	Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder
title_fullStr	Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder
title_full_unstemmed	Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder
title_sort	frontotemporal white matter in adolescents with, and at-risk for, bipolar disorder
description	Frontotemporal neural systems are highly implicated in the emotional dysregulation characteristic of bipolar disorder (BD). Convergent genetic, postmortem, behavioral and neuroimaging evidence suggests abnormalities in the development of frontotemporal white matter (WM) in the pathophysiology of BD. This review discusses evidence for the involvement of abnormal WM development in BD during adolescence, with a focus on frontotemporal WM. Findings from diffusion tensor imaging (DTI) studies in adults and adolescents are reviewed to explore possible progressive WM abnormalities in the disorder. Intra- and interhemispheric frontotemporal abnormalities were reported in adults with BD. Although evidence in children and adolescents with BD to date has been limited, similar intrahemispheric and interhemispheric findings have also been reported. The findings in youths suggest that these abnormalities may represent a trait marker present early in the course of BD. Functional connectivity studies, demonstrating a relationship between WM abnormalities and frontotemporal dysfunction in BD, and DTI studies of vulnerability in first-degree relatives of individuals with BD, are discussed. Together, findings suggest the involvement of abnormal frontotemporal WM development in the pathophysiology of BD and that these abnormalities may be early trait markers of vulnerability; however, more studies are critically needed.
publisher	MDPI
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449671/
_version_	1613229701414780928

Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder

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