Vitamin D—update for the pediatric rheumatologists
Vitamin D, upon its discovery one century ago, was classified as a vitamin. This classification still greatly affects our perception about its biological role. 1,25(OH)2D (now known as the D hormone) is a pleiotropic steroid hormone that has multiple biologic effects. It is integral to the regulatio...
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| Format: | Online |
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BioMed Central
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446840/ |
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pubmed-44468402015-05-29 Vitamin D—update for the pediatric rheumatologists Vojinovic, Jelena Cimaz, Rolando Review Vitamin D, upon its discovery one century ago, was classified as a vitamin. This classification still greatly affects our perception about its biological role. 1,25(OH)2D (now known as the D hormone) is a pleiotropic steroid hormone that has multiple biologic effects. It is integral to the regulation of calcium homeostasis and bone turnover as well as having anti-proliferative, pro-differentiation, anti-bacterial, immunomodulatory and anti-inflammatory properties within the body in various cells and tissues. Vitamin D (cholecalciferol) should be considered a nutritional substrate that must be ingested or synthesized in sufficient amounts for the further synthesis of the very important regulatory steroid hormone (D hormone), especially in patients with pediatric rheumatic diseases (PRD). BioMed Central 2015-05-29 /pmc/articles/PMC4446840/ /pubmed/26022196 http://dx.doi.org/10.1186/s12969-015-0017-9 Text en © Vojinovic and Rolando; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Vojinovic, Jelena Cimaz, Rolando |
| spellingShingle |
Vojinovic, Jelena Cimaz, Rolando Vitamin D—update for the pediatric rheumatologists |
| author_facet |
Vojinovic, Jelena Cimaz, Rolando |
| author_sort |
Vojinovic, Jelena |
| title |
Vitamin D—update for the pediatric rheumatologists |
| title_short |
Vitamin D—update for the pediatric rheumatologists |
| title_full |
Vitamin D—update for the pediatric rheumatologists |
| title_fullStr |
Vitamin D—update for the pediatric rheumatologists |
| title_full_unstemmed |
Vitamin D—update for the pediatric rheumatologists |
| title_sort |
vitamin d—update for the pediatric rheumatologists |
| description |
Vitamin D, upon its discovery one century ago, was classified as a vitamin. This classification still greatly affects our perception about its biological role. 1,25(OH)2D (now known as the D hormone) is a pleiotropic steroid hormone that has multiple biologic effects. It is integral to the regulation of calcium homeostasis and bone turnover as well as having anti-proliferative, pro-differentiation, anti-bacterial, immunomodulatory and anti-inflammatory properties within the body in various cells and tissues. Vitamin D (cholecalciferol) should be considered a nutritional substrate that must be ingested or synthesized in sufficient amounts for the further synthesis of the very important regulatory steroid hormone (D hormone), especially in patients with pediatric rheumatic diseases (PRD). |
| publisher |
BioMed Central |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446840/ |
| _version_ |
1613228742701744128 |