Key challenges for the creation and maintenance of specialist protein resources

As the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material of individual articles, all the way to major reference databases with professio...

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Main Authors:	Holliday, Gemma L, Bairoch, Amos, Bagos, Pantelis G, Chatonnet, Arnaud, Craik, David J, Finn, Robert D, Henrissat, Bernard, Landsman, David, Manning, Gerard, Nagano, Nozomi, O’Donovan, Claire, Pruitt, Kim D, Rawlings, Neil D, Saier, Milton, Sowdhamini, Ramanathan, Spedding, Michael, Srinivasan, Narayanaswamy, Vriend, Gert, Babbitt, Patricia C, Bateman, Alex
Format:	Online
Language:	English
Published:	John Wiley & Sons, Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446195/

id	pubmed-4446195
recordtype	oai_dc
spelling	pubmed-44461952015-06-01 Key challenges for the creation and maintenance of specialist protein resources Holliday, Gemma L Bairoch, Amos Bagos, Pantelis G Chatonnet, Arnaud Craik, David J Finn, Robert D Henrissat, Bernard Landsman, David Manning, Gerard Nagano, Nozomi O’Donovan, Claire Pruitt, Kim D Rawlings, Neil D Saier, Milton Sowdhamini, Ramanathan Spedding, Michael Srinivasan, Narayanaswamy Vriend, Gert Babbitt, Patricia C Bateman, Alex Perspectives As the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material of individual articles, all the way to major reference databases with professional staff and long-term funding. Specialist protein resources fill an important middle ground, providing interactive web interfaces to their databases for a focused topic or family of proteins, using specialized approaches that are not feasible in the major reference databases. Many are labors of love, run by a single lab with little or no dedicated funding and there are many challenges to building and maintaining them. This perspective arose from a meeting of several specialist protein resources and major reference databases held at the Wellcome Trust Genome Campus (Cambridge, UK) on August 11 and 12, 2014. During this meeting some common key challenges involved in creating and maintaining such resources were discussed, along with various approaches to address them. In laying out these challenges, we aim to inform users about how these issues impact our resources and illustrate ways in which our working together could enhance their accuracy, currency, and overall value. Proteins 2015; 83:1005–1013. © 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc. John Wiley & Sons, Ltd 2015-06 2015-04-22 /pmc/articles/PMC4446195/ /pubmed/25820941 http://dx.doi.org/10.1002/prot.24803 Text en © 2015 The Authors. Proteins published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Holliday, Gemma L Bairoch, Amos Bagos, Pantelis G Chatonnet, Arnaud Craik, David J Finn, Robert D Henrissat, Bernard Landsman, David Manning, Gerard Nagano, Nozomi O’Donovan, Claire Pruitt, Kim D Rawlings, Neil D Saier, Milton Sowdhamini, Ramanathan Spedding, Michael Srinivasan, Narayanaswamy Vriend, Gert Babbitt, Patricia C Bateman, Alex
spellingShingle	Holliday, Gemma L Bairoch, Amos Bagos, Pantelis G Chatonnet, Arnaud Craik, David J Finn, Robert D Henrissat, Bernard Landsman, David Manning, Gerard Nagano, Nozomi O’Donovan, Claire Pruitt, Kim D Rawlings, Neil D Saier, Milton Sowdhamini, Ramanathan Spedding, Michael Srinivasan, Narayanaswamy Vriend, Gert Babbitt, Patricia C Bateman, Alex Key challenges for the creation and maintenance of specialist protein resources
author_facet	Holliday, Gemma L Bairoch, Amos Bagos, Pantelis G Chatonnet, Arnaud Craik, David J Finn, Robert D Henrissat, Bernard Landsman, David Manning, Gerard Nagano, Nozomi O’Donovan, Claire Pruitt, Kim D Rawlings, Neil D Saier, Milton Sowdhamini, Ramanathan Spedding, Michael Srinivasan, Narayanaswamy Vriend, Gert Babbitt, Patricia C Bateman, Alex
author_sort	Holliday, Gemma L
title	Key challenges for the creation and maintenance of specialist protein resources
title_short	Key challenges for the creation and maintenance of specialist protein resources
title_full	Key challenges for the creation and maintenance of specialist protein resources
title_fullStr	Key challenges for the creation and maintenance of specialist protein resources
title_full_unstemmed	Key challenges for the creation and maintenance of specialist protein resources
title_sort	key challenges for the creation and maintenance of specialist protein resources
description	As the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material of individual articles, all the way to major reference databases with professional staff and long-term funding. Specialist protein resources fill an important middle ground, providing interactive web interfaces to their databases for a focused topic or family of proteins, using specialized approaches that are not feasible in the major reference databases. Many are labors of love, run by a single lab with little or no dedicated funding and there are many challenges to building and maintaining them. This perspective arose from a meeting of several specialist protein resources and major reference databases held at the Wellcome Trust Genome Campus (Cambridge, UK) on August 11 and 12, 2014. During this meeting some common key challenges involved in creating and maintaining such resources were discussed, along with various approaches to address them. In laying out these challenges, we aim to inform users about how these issues impact our resources and illustrate ways in which our working together could enhance their accuracy, currency, and overall value. Proteins 2015; 83:1005–1013. © 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc.
publisher	John Wiley & Sons, Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446195/
_version_	1613228445270016000

Key challenges for the creation and maintenance of specialist protein resources

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