Xanthohumol Inhibits Notch Signaling and Induces Apoptosis in Hepatocellular Carcinoma

Despite improvement in therapeutic strategies, median survival in advanced hepatocellular carcinoma (HCC) remains less than one year. Therefore, molecularly targeted compounds with less toxic profiles are needed. Xanthohumol (XN), a prenylated chalcone has been shown to have anti-proliferative effec...

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Bibliographic Details
Main Authors: Kunnimalaiyaan, Selvi, Sokolowski, Kevin M., Balamurugan, Mariappan, Gamblin, T. Clark, Kunnimalaiyaan, Muthusamy
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444108/