Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

•Expression of AQP2 restores drug susceptibility in a resistant Trypanosoma brucei gambiense isolate.•The AQP2/3 chimera from the resistant isolate does not complement AQP2 deletion.•Hence AQP2/3 chimerization accompanied by loss of AQP2 is the cause of drug resistance.

Bibliographic Details
Main Authors: Graf, Fabrice E., Baker, Nicola, Munday, Jane C., de Koning, Harry P., Horn, David, Mäser, Pascal
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443405/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443405/

Similar Items