Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe

More than one million chikungunya cases have been reported in the Americas since October 2013, when the Asian genotype of chikungunya virus (CHIKV) was imported by a traveller returning from Asia. CHIKV is mainly transmitted in urban areas by the domestic mosquitoes Aedes aegypti and Aedes albopictu...

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Main Authors:	Vega-Rúa, Anubis, Lourenço-de-Oliveira, Ricardo, Mousson, Laurence, Vazeille, Marie, Fuchs, Sappho, Yébakima, André, Gustave, Joel, Girod, Romain, Dusfour, Isabelle, Leparc-Goffart, Isabelle, Vanlandingham, Dana L., Huang, Yan-Jang S., Lounibos, L. Philip, Mohamed Ali, Souand, Nougairede, Antoine, de Lamballerie, Xavier, Failloux, Anna-Bella
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439146/

id	pubmed-4439146
recordtype	oai_dc
spelling	pubmed-44391462015-05-29 Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe Vega-Rúa, Anubis Lourenço-de-Oliveira, Ricardo Mousson, Laurence Vazeille, Marie Fuchs, Sappho Yébakima, André Gustave, Joel Girod, Romain Dusfour, Isabelle Leparc-Goffart, Isabelle Vanlandingham, Dana L. Huang, Yan-Jang S. Lounibos, L. Philip Mohamed Ali, Souand Nougairede, Antoine de Lamballerie, Xavier Failloux, Anna-Bella Research Article More than one million chikungunya cases have been reported in the Americas since October 2013, when the Asian genotype of chikungunya virus (CHIKV) was imported by a traveller returning from Asia. CHIKV is mainly transmitted in urban areas by the domestic mosquitoes Aedes aegypti and Aedes albopictus. In this study, we evaluate the potential for the CHIKV circulating in the Caribbean to initiate outbreaks in Aedes-infested regions of continental America and Europe by assessing the ability of local mosquitoes to experimentally transmit the virus. Mosquitoes were exposed to a blood-meal containing the virus which must overcome several barriers to infect various tissues in the vector before being secreted in the mosquito saliva when biting a host. We found that Ae. aegypti and Ae. albopictus transmitted similarly the virus. When exposing Ae. albopictus from Europe at a temperature of 20°C after infection, we detect a significant drop of CHIKV transmission potential. Our results suggest that the CHIKV outbreak in the Americas could potentially spread throughout Ae. aegypti- and Ae. albopictus-infested regions of the Americas however with a limited risk of spillovers in Ae. albopictus-infested regions in Europe. These data will be useful for adapting vector control strategies and epidemiological surveillance. Public Library of Science 2015-05-20 /pmc/articles/PMC4439146/ /pubmed/25993633 http://dx.doi.org/10.1371/journal.pntd.0003780 Text en © 2015 Vega-Rúa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Vega-Rúa, Anubis Lourenço-de-Oliveira, Ricardo Mousson, Laurence Vazeille, Marie Fuchs, Sappho Yébakima, André Gustave, Joel Girod, Romain Dusfour, Isabelle Leparc-Goffart, Isabelle Vanlandingham, Dana L. Huang, Yan-Jang S. Lounibos, L. Philip Mohamed Ali, Souand Nougairede, Antoine de Lamballerie, Xavier Failloux, Anna-Bella
spellingShingle	Vega-Rúa, Anubis Lourenço-de-Oliveira, Ricardo Mousson, Laurence Vazeille, Marie Fuchs, Sappho Yébakima, André Gustave, Joel Girod, Romain Dusfour, Isabelle Leparc-Goffart, Isabelle Vanlandingham, Dana L. Huang, Yan-Jang S. Lounibos, L. Philip Mohamed Ali, Souand Nougairede, Antoine de Lamballerie, Xavier Failloux, Anna-Bella Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe
author_facet	Vega-Rúa, Anubis Lourenço-de-Oliveira, Ricardo Mousson, Laurence Vazeille, Marie Fuchs, Sappho Yébakima, André Gustave, Joel Girod, Romain Dusfour, Isabelle Leparc-Goffart, Isabelle Vanlandingham, Dana L. Huang, Yan-Jang S. Lounibos, L. Philip Mohamed Ali, Souand Nougairede, Antoine de Lamballerie, Xavier Failloux, Anna-Bella
author_sort	Vega-Rúa, Anubis
title	Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe
title_short	Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe
title_full	Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe
title_fullStr	Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe
title_full_unstemmed	Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe
title_sort	chikungunya virus transmission potential by local aedes mosquitoes in the americas and europe
description	More than one million chikungunya cases have been reported in the Americas since October 2013, when the Asian genotype of chikungunya virus (CHIKV) was imported by a traveller returning from Asia. CHIKV is mainly transmitted in urban areas by the domestic mosquitoes Aedes aegypti and Aedes albopictus. In this study, we evaluate the potential for the CHIKV circulating in the Caribbean to initiate outbreaks in Aedes-infested regions of continental America and Europe by assessing the ability of local mosquitoes to experimentally transmit the virus. Mosquitoes were exposed to a blood-meal containing the virus which must overcome several barriers to infect various tissues in the vector before being secreted in the mosquito saliva when biting a host. We found that Ae. aegypti and Ae. albopictus transmitted similarly the virus. When exposing Ae. albopictus from Europe at a temperature of 20°C after infection, we detect a significant drop of CHIKV transmission potential. Our results suggest that the CHIKV outbreak in the Americas could potentially spread throughout Ae. aegypti- and Ae. albopictus-infested regions of the Americas however with a limited risk of spillovers in Ae. albopictus-infested regions in Europe. These data will be useful for adapting vector control strategies and epidemiological surveillance.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439146/
_version_	1613226177322811392

Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe

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