Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines

Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines

In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells (iPSCs) to show that mutations in PARK2 alter neuronal proliferation. The percentage of TH+ neurons was decreased in Parkinson’s disease (PD) patient-derived neurons carrying various mutations in PARK2 compared...

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Bibliographic Details
Main Authors: Shaltouki, Atossa, Sivapatham, Renuka, Pei, Ying, Gerencser, Akos A., Momčilović, Olga, Rao, Mahendra S., Zeng, Xianmin
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437475/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437475/

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