Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats

Conditioned taste aversion (CTA) is an adaptive behavior that benefits survival of animals including humans and also serves as a powerful model to study the neural mechanisms of learning. Memory formation is a necessary component of CTA learning and involves neural processing and regulation of gene...

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Main Authors:	Panguluri, Siva K., Kuwabara, Nobuyuki, Cooper, Nigel, Tipparaju, Srinivas M., Sneed, Kevin B., Lundy, Robert F.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437262/

id	pubmed-4437262
recordtype	oai_dc
spelling	pubmed-44372622015-08-27 Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats Panguluri, Siva K. Kuwabara, Nobuyuki Cooper, Nigel Tipparaju, Srinivas M. Sneed, Kevin B. Lundy, Robert F. Research Article Conditioned taste aversion (CTA) is an adaptive behavior that benefits survival of animals including humans and also serves as a powerful model to study the neural mechanisms of learning. Memory formation is a necessary component of CTA learning and involves neural processing and regulation of gene expression in the amygdala. Many studies have been focused on the identification of intracellular signaling cascades involved in CTA, but not late responsive genes underlying the long-lasting behavioral plasticity. In this study, we explored in silico experiments to identify persistent changes in gene expression associated with CTA in rats. We used oligonucleotide microarrays to identify 248 genes in the amygdala regulated by CTA. Pathway Studio and IPA software analyses showed that the differentially expressed genes in the amygdala fall in diverse functional categories such as behavior, psychological disorders, nervous system development and function, and cell-to-cell signaling. Conditioned taste aversion is a complex behavioral trait which involves association of visceral and taste inputs, consolidation of taste and visceral information, memory formation, retrieval of stored information, and extinction phase. In silico analysis of differentially expressed genes is therefore necessary to manipulate specific phase/stage of CTA to understand the molecular insight. Hindawi Publishing Corporation 2013 2013-05-23 /pmc/articles/PMC4437262/ /pubmed/26317099 http://dx.doi.org/10.1155/2013/739764 Text en Copyright © 2013 Siva K. Panguluri et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Panguluri, Siva K. Kuwabara, Nobuyuki Cooper, Nigel Tipparaju, Srinivas M. Sneed, Kevin B. Lundy, Robert F.
spellingShingle	Panguluri, Siva K. Kuwabara, Nobuyuki Cooper, Nigel Tipparaju, Srinivas M. Sneed, Kevin B. Lundy, Robert F. Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
author_facet	Panguluri, Siva K. Kuwabara, Nobuyuki Cooper, Nigel Tipparaju, Srinivas M. Sneed, Kevin B. Lundy, Robert F.
author_sort	Panguluri, Siva K.
title	Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
title_short	Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
title_full	Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
title_fullStr	Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
title_full_unstemmed	Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats
title_sort	gene network analysis in amygdala following taste aversion learning in rats
description	Conditioned taste aversion (CTA) is an adaptive behavior that benefits survival of animals including humans and also serves as a powerful model to study the neural mechanisms of learning. Memory formation is a necessary component of CTA learning and involves neural processing and regulation of gene expression in the amygdala. Many studies have been focused on the identification of intracellular signaling cascades involved in CTA, but not late responsive genes underlying the long-lasting behavioral plasticity. In this study, we explored in silico experiments to identify persistent changes in gene expression associated with CTA in rats. We used oligonucleotide microarrays to identify 248 genes in the amygdala regulated by CTA. Pathway Studio and IPA software analyses showed that the differentially expressed genes in the amygdala fall in diverse functional categories such as behavior, psychological disorders, nervous system development and function, and cell-to-cell signaling. Conditioned taste aversion is a complex behavioral trait which involves association of visceral and taste inputs, consolidation of taste and visceral information, memory formation, retrieval of stored information, and extinction phase. In silico analysis of differentially expressed genes is therefore necessary to manipulate specific phase/stage of CTA to understand the molecular insight.
publisher	Hindawi Publishing Corporation
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437262/
_version_	1613225477199101952

Gene Network Analysis in Amygdala following Taste Aversion Learning in Rats

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