Designation of a Novel DKK1 Multiepitope DNA Vaccine and Inhibition of Bone Loss in Collagen-Induced Arthritic Mice

Designation of a Novel DKK1 Multiepitope DNA Vaccine and Inhibition of Bone Loss in Collagen-Induced Arthritic Mice

Dickkopf-1 (DKK1), a secretory inhibitor of canonical Wnt signaling, plays a critical role in certain bone loss diseases. Studies have shown that serum levels of DKK1 are significantly higher in rheumatoid arthritis (RA) patients and are correlated with the severity of the disease, which indicates t...

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Bibliographic Details
Main Authors: Zhang, Xiaoqing, Liu, Sibo, Li, Shentao, Du, Yuxuan, Dou, Yunpeng, Li, Zhanguo, Yuan, Huihui, Zhao, Wenming
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436448/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436448/

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