Activity-dependent plasticity of mouse hippocampal assemblies in vitro

Memory formation is associated with the generation of transiently stable neuronal assemblies. In hippocampal networks, such groups of functionally coupled neurons express highly ordered spatiotemporal activity patterns which are coordinated by local network oscillations. One of these patterns, sharp...

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Main Authors:	Keller, Martin K., Draguhn, Andreas, Both, Martin, Reichinnek, Susanne
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435105/

id	pubmed-4435105
recordtype	oai_dc
spelling	pubmed-44351052015-06-03 Activity-dependent plasticity of mouse hippocampal assemblies in vitro Keller, Martin K. Draguhn, Andreas Both, Martin Reichinnek, Susanne Neuroscience Memory formation is associated with the generation of transiently stable neuronal assemblies. In hippocampal networks, such groups of functionally coupled neurons express highly ordered spatiotemporal activity patterns which are coordinated by local network oscillations. One of these patterns, sharp wave-ripple complexes (SPW-R), repetitively activates previously established groups of memory-encoding neurons, thereby supporting memory consolidation. This function implies that repetition of specific SPW-R induces plastic changes which render the underlying neuronal assemblies more stable. We modeled this repetitive activation in an in vitro model of SPW-R in mouse hippocampal slices. Weak electrical stimulation upstream of the CA3-CA1 networks reliably induced SPW-R of stereotypic waveform, thus representing re-activation of similar neuronal activity patterns. Frequent repetition of these patterns (100 times) reduced the variance of both, evoked and spontaneous SPW-R waveforms, indicating stabilization of pre-existing assemblies. These effects were most pronounced in the CA1 subfield and depended on the timing of stimulation relative to spontaneous SPW-R. Additionally, plasticity of SPW-R was blocked by application of a NMDA receptor antagonist, suggesting a role for associative synaptic plasticity in this process. Thus, repetitive activation of specific patterns of SPW-R causes stabilization of memory-related networks. Frontiers Media S.A. 2015-05-18 /pmc/articles/PMC4435105/ /pubmed/26041998 http://dx.doi.org/10.3389/fncir.2015.00021 Text en Copyright © 2015 Keller, Draguhn, Both and Reichinnek. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Keller, Martin K. Draguhn, Andreas Both, Martin Reichinnek, Susanne
spellingShingle	Keller, Martin K. Draguhn, Andreas Both, Martin Reichinnek, Susanne Activity-dependent plasticity of mouse hippocampal assemblies in vitro
author_facet	Keller, Martin K. Draguhn, Andreas Both, Martin Reichinnek, Susanne
author_sort	Keller, Martin K.
title	Activity-dependent plasticity of mouse hippocampal assemblies in vitro
title_short	Activity-dependent plasticity of mouse hippocampal assemblies in vitro
title_full	Activity-dependent plasticity of mouse hippocampal assemblies in vitro
title_fullStr	Activity-dependent plasticity of mouse hippocampal assemblies in vitro
title_full_unstemmed	Activity-dependent plasticity of mouse hippocampal assemblies in vitro
title_sort	activity-dependent plasticity of mouse hippocampal assemblies in vitro
description	Memory formation is associated with the generation of transiently stable neuronal assemblies. In hippocampal networks, such groups of functionally coupled neurons express highly ordered spatiotemporal activity patterns which are coordinated by local network oscillations. One of these patterns, sharp wave-ripple complexes (SPW-R), repetitively activates previously established groups of memory-encoding neurons, thereby supporting memory consolidation. This function implies that repetition of specific SPW-R induces plastic changes which render the underlying neuronal assemblies more stable. We modeled this repetitive activation in an in vitro model of SPW-R in mouse hippocampal slices. Weak electrical stimulation upstream of the CA3-CA1 networks reliably induced SPW-R of stereotypic waveform, thus representing re-activation of similar neuronal activity patterns. Frequent repetition of these patterns (100 times) reduced the variance of both, evoked and spontaneous SPW-R waveforms, indicating stabilization of pre-existing assemblies. These effects were most pronounced in the CA1 subfield and depended on the timing of stimulation relative to spontaneous SPW-R. Additionally, plasticity of SPW-R was blocked by application of a NMDA receptor antagonist, suggesting a role for associative synaptic plasticity in this process. Thus, repetitive activation of specific patterns of SPW-R causes stabilization of memory-related networks.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435105/
_version_	1613224680816115712

Activity-dependent plasticity of mouse hippocampal assemblies in vitro

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