The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis

Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relati...

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Main Authors:	Yetkin, D. O., Dogantekin, B.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433708/

id	pubmed-4433708
recordtype	oai_dc
spelling	pubmed-44337082015-06-10 The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis Yetkin, D. O. Dogantekin, B. Research Article Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients. Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL. Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group. Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism. Hindawi Publishing Corporation 2015 2015-05-03 /pmc/articles/PMC4433708/ /pubmed/26064115 http://dx.doi.org/10.1155/2015/952729 Text en Copyright © 2015 D. O. Yetkin and B. Dogantekin. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yetkin, D. O. Dogantekin, B.
spellingShingle	Yetkin, D. O. Dogantekin, B. The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis
author_facet	Yetkin, D. O. Dogantekin, B.
author_sort	Yetkin, D. O.
title	The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis
title_short	The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis
title_full	The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis
title_fullStr	The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis
title_full_unstemmed	The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis
title_sort	lipid parameters and lipoprotein(a) excess in hashimoto thyroiditis
description	Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. The aim of this study is to investigate the relationship between Lp(a) levels and thyroid hormones in Hashimoto patients. Method. 154 premenopausal female Hashimoto patients (48 patients with overthypothyroid (OH), 50 patients with subclinical hypothyroid (SH), and 56 patients with euthyroid Hashimoto to (EH)) were enrolled in this study. The control group consists of 50 age matched volunteers. In every group, thyroid function tests and lipid parameters with Lp(a) were measured. Lp(a) excess was defined as Lp(a) > 30 mg/dL. Results. Total-C, LDL-C, TG, and Lp(a) levels were increased in Hashimoto group. Total-C, LDL-C, and TG levels were higher in SH group than in the control group. Total-C and LDL-C levels were also higher in EH group compared to controls. Lp(a) levels were similar in SH and EH groups with controls. However, excess Lp(a) was more common in subclinical hypothyroid and euthyroid Hashimoto group than in the control group. Conclusion. The Total-C and LDL-C levels and excess Lp(a) were higher even in euthyroid Hashimoto patients. Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433708/
_version_	1613224203709841408

The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis

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