Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

The membrane localization and activation of cytoskeletal protein talin are key steps to initiate integrin transmembrane receptors activation, which mediates many cellular adhesive responses such as cell migration, spreading, and proliferation. RIAM, a membrane anchor and small GTPase RAP1 effector,...

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Bibliographic Details
Main Authors: Yang, Jun, Zhu, Liang, Zhang, Hao, Hirbawi, Jamila, Fukuda, Koichi, Dwivedi, Pallavi, Liu, Jianmin, Byzova, Tatiana, Plow, Edward F., Wu, Jinhua, Qin, Jun
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432866/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432866/

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