Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier

The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the ‘cochlear amplifier' in each ear. Such efferent feedback is important for promoting discrimination of sounds in background noise, sou...

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Main Authors:	Froud, Kristina E., Wong, Ann Chi Yan, Cederholm, Jennie M. E., Klugmann, Matthias, Sandow, Shaun L., Julien, Jean-Pierre, Ryan, Allen F., Housley, Gary D.
Format:	Online
Language:	English
Published:	Nature Pub. Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432632/

id	pubmed-4432632
recordtype	oai_dc
spelling	pubmed-44326322015-05-23 Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier Froud, Kristina E. Wong, Ann Chi Yan Cederholm, Jennie M. E. Klugmann, Matthias Sandow, Shaun L. Julien, Jean-Pierre Ryan, Allen F. Housley, Gary D. Article The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the ‘cochlear amplifier' in each ear. Such efferent feedback is important for promoting discrimination of sounds in background noise, sound localization and protecting the cochleae from acoustic overstimulation. However, the sensory driver for the olivocochlear reflex is unknown. Here, we resolve this longstanding question using a mouse model null for the gene encoding the type III intermediate filament peripherin (Prph). Prph(−/−) mice lacked type II spiral ganglion neuron innervation of the outer hair cells, whereas innervation of the inner hair cells by type I spiral ganglion neurons was normal. Compared with Prph(+/+) controls, both contralateral and ipsilateral olivocochlear efferent-mediated suppression of the cochlear amplifier were absent in Prph(−/−) mice, demonstrating that outer hair cells and their type II afferents constitute the sensory drive for the olivocochlear efferent reflex. Nature Pub. Group 2015-05-12 /pmc/articles/PMC4432632/ /pubmed/25965946 http://dx.doi.org/10.1038/ncomms8115 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Froud, Kristina E. Wong, Ann Chi Yan Cederholm, Jennie M. E. Klugmann, Matthias Sandow, Shaun L. Julien, Jean-Pierre Ryan, Allen F. Housley, Gary D.
spellingShingle	Froud, Kristina E. Wong, Ann Chi Yan Cederholm, Jennie M. E. Klugmann, Matthias Sandow, Shaun L. Julien, Jean-Pierre Ryan, Allen F. Housley, Gary D. Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
author_facet	Froud, Kristina E. Wong, Ann Chi Yan Cederholm, Jennie M. E. Klugmann, Matthias Sandow, Shaun L. Julien, Jean-Pierre Ryan, Allen F. Housley, Gary D.
author_sort	Froud, Kristina E.
title	Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
title_short	Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
title_full	Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
title_fullStr	Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
title_full_unstemmed	Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
title_sort	type ii spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier
description	The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the medial olivocochlear efferent reflex, which suppresses the gain of the ‘cochlear amplifier' in each ear. Such efferent feedback is important for promoting discrimination of sounds in background noise, sound localization and protecting the cochleae from acoustic overstimulation. However, the sensory driver for the olivocochlear reflex is unknown. Here, we resolve this longstanding question using a mouse model null for the gene encoding the type III intermediate filament peripherin (Prph). Prph(−/−) mice lacked type II spiral ganglion neuron innervation of the outer hair cells, whereas innervation of the inner hair cells by type I spiral ganglion neurons was normal. Compared with Prph(+/+) controls, both contralateral and ipsilateral olivocochlear efferent-mediated suppression of the cochlear amplifier were absent in Prph(−/−) mice, demonstrating that outer hair cells and their type II afferents constitute the sensory drive for the olivocochlear efferent reflex.
publisher	Nature Pub. Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432632/
_version_	1613223850180345856

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier

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