Male obesity and subfertility, is it really about increased adiposity?
The prevalence of overweight and obesity in reproductive-aged men is increasing worldwide, with >70% of men >18 years classified as overweight or obese in some western nations. Male obesity is associated with male subfertility, impairing sex hormones, reducing sperm counts, increasing oxidativ...
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| Format: | Online |
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Medknow Publications & Media Pvt Ltd
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430951/ |
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pubmed-44309512015-06-01 Male obesity and subfertility, is it really about increased adiposity? McPherson, Nicole O Lane, Michelle Invited Review The prevalence of overweight and obesity in reproductive-aged men is increasing worldwide, with >70% of men >18 years classified as overweight or obese in some western nations. Male obesity is associated with male subfertility, impairing sex hormones, reducing sperm counts, increasing oxidative sperm DNA damage and changing the epigenetic status of sperm. These changes to sperm function as a result of obesity, are further associated with impaired embryo development, reduced live birth rates and increased miscarriage rates in humans. Animal models have suggested that these adverse reproductive effects can be transmitted to the offspring; suggesting that men's health at conception may affect the health of their children. In addition to higher adiposity, male obesity is associated with comorbidities, including metabolic syndrome, hypercholesterolemia, hyperleptinemia and a pro-inflammatory state, all which have independently been linked with male subfertility. Taken together, these findings suggest that the effects of male obesity on fertility are likely multifactorial, with associated comorbidities also influencing sperm, pregnancy and subsequent child health. Medknow Publications & Media Pvt Ltd 2015 2015-01-23 /pmc/articles/PMC4430951/ /pubmed/25652636 http://dx.doi.org/10.4103/1008-682X.148076 Text en Copyright: © Asian Journal of Andrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
McPherson, Nicole O Lane, Michelle |
| spellingShingle |
McPherson, Nicole O Lane, Michelle Male obesity and subfertility, is it really about increased adiposity? |
| author_facet |
McPherson, Nicole O Lane, Michelle |
| author_sort |
McPherson, Nicole O |
| title |
Male obesity and subfertility, is it really about increased adiposity? |
| title_short |
Male obesity and subfertility, is it really about increased adiposity? |
| title_full |
Male obesity and subfertility, is it really about increased adiposity? |
| title_fullStr |
Male obesity and subfertility, is it really about increased adiposity? |
| title_full_unstemmed |
Male obesity and subfertility, is it really about increased adiposity? |
| title_sort |
male obesity and subfertility, is it really about increased adiposity? |
| description |
The prevalence of overweight and obesity in reproductive-aged men is increasing worldwide, with >70% of men >18 years classified as overweight or obese in some western nations. Male obesity is associated with male subfertility, impairing sex hormones, reducing sperm counts, increasing oxidative sperm DNA damage and changing the epigenetic status of sperm. These changes to sperm function as a result of obesity, are further associated with impaired embryo development, reduced live birth rates and increased miscarriage rates in humans. Animal models have suggested that these adverse reproductive effects can be transmitted to the offspring; suggesting that men's health at conception may affect the health of their children. In addition to higher adiposity, male obesity is associated with comorbidities, including metabolic syndrome, hypercholesterolemia, hyperleptinemia and a pro-inflammatory state, all which have independently been linked with male subfertility. Taken together, these findings suggest that the effects of male obesity on fertility are likely multifactorial, with associated comorbidities also influencing sperm, pregnancy and subsequent child health. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430951/ |
| _version_ |
1613223224038916096 |