Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma

Introduction. Malignant Pleural Mesothelioma (MPM) is a rare disease, even less frequently described in minority patients. We used a large population-based dataset to study the role of race in MPM presentation, treatment, and survival. Methods. All cases of pathologically proven MPM were identified...

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Main Authors:	Taioli, Emanuela, Wolf, Andrea S., Moline, Jacqueline M., Camacho-Rivera, Marlene, Flores, Raja M.
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430630/

id	pubmed-4430630
recordtype	oai_dc
spelling	pubmed-44306302015-06-10 Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma Taioli, Emanuela Wolf, Andrea S. Moline, Jacqueline M. Camacho-Rivera, Marlene Flores, Raja M. Research Article Introduction. Malignant Pleural Mesothelioma (MPM) is a rare disease, even less frequently described in minority patients. We used a large population-based dataset to study the role of race in MPM presentation, treatment, and survival. Methods. All cases of pathologically proven MPM were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Age, sex, diagnosis year, stage, cancer-directed surgery, radiation, and vital status were analyzed according to self-reported race (black or white). Results. There were 13,046 white and 688 black MPM patients (incidence: 1.1 per 100,000 whites; 0.5 per 100,000 blacks; age-adjusted, p = 0.01). Black patients were more likely to be female, younger, and with advanced stage and less likely to undergo cancer-directed surgery than whites, after adjustment by stage. On multivariable analysis, younger age and having surgery were associated with longer survival for both cohorts; female gender (HR 0.82 (0.77–0.88)) and early stage at diagnosis (HR 0.83 (0.76–0.90)) were predictive of longer survival in white, but not in black, patients. Conclusions. Surgery was associated with improved survival for both black and white MPM patients. However, black patients were less likely to undergo cancer-directed surgery. Increased surgical intervention in MPM black patients with early stage disease may improve their survival. Hindawi Publishing Corporation 2015 2015-04-30 /pmc/articles/PMC4430630/ /pubmed/26063951 http://dx.doi.org/10.1155/2015/282145 Text en Copyright © 2015 Emanuela Taioli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Taioli, Emanuela Wolf, Andrea S. Moline, Jacqueline M. Camacho-Rivera, Marlene Flores, Raja M.
spellingShingle	Taioli, Emanuela Wolf, Andrea S. Moline, Jacqueline M. Camacho-Rivera, Marlene Flores, Raja M. Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma
author_facet	Taioli, Emanuela Wolf, Andrea S. Moline, Jacqueline M. Camacho-Rivera, Marlene Flores, Raja M.
author_sort	Taioli, Emanuela
title	Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma
title_short	Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma
title_full	Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma
title_fullStr	Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma
title_full_unstemmed	Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma
title_sort	frequency of surgery in black patients with malignant pleural mesothelioma
description	Introduction. Malignant Pleural Mesothelioma (MPM) is a rare disease, even less frequently described in minority patients. We used a large population-based dataset to study the role of race in MPM presentation, treatment, and survival. Methods. All cases of pathologically proven MPM were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Age, sex, diagnosis year, stage, cancer-directed surgery, radiation, and vital status were analyzed according to self-reported race (black or white). Results. There were 13,046 white and 688 black MPM patients (incidence: 1.1 per 100,000 whites; 0.5 per 100,000 blacks; age-adjusted, p = 0.01). Black patients were more likely to be female, younger, and with advanced stage and less likely to undergo cancer-directed surgery than whites, after adjustment by stage. On multivariable analysis, younger age and having surgery were associated with longer survival for both cohorts; female gender (HR 0.82 (0.77–0.88)) and early stage at diagnosis (HR 0.83 (0.76–0.90)) were predictive of longer survival in white, but not in black, patients. Conclusions. Surgery was associated with improved survival for both black and white MPM patients. However, black patients were less likely to undergo cancer-directed surgery. Increased surgical intervention in MPM black patients with early stage disease may improve their survival.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430630/
_version_	1613223094009200640

Frequency of Surgery in Black Patients with Malignant Pleural Mesothelioma

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