Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy

Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy

•Human ovarian surface epithelium (OSE) and epithelial ovarian cancer (EOC) cells have the capacity for local metabolism of estrogen.•Estrogen is differentially metabolized in OSE and EOC cells, with E2 formation from conjugated estrogen predominating in cancer cells.•Inflammatory cytokines augment...

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Bibliographic Details
Main Authors: Ren, Xia, Wu, Xuan, Hillier, Stephen G., Fegan, K. Scott, Critchley, Hilary O.D., Mason, J. Ian, Sarvi, Sana, Harlow, Christopher R.
Format: Online
Language:English
Published: Pergamon 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429663/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429663/

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