4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling

4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling

4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily (TNFRSF), is primarily expressed on activated T cells and is known to enhance proliferation of T cells, prevent activation-induced cell death, and promote memory formation of CD8+ T cells. In particular, it is well acknowledge...

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Bibliographic Details
Main Authors: Oh, Ho S., Choi, Beom K., Kim, Young H., Lee, Don G., Hwang, Sunhee, Lee, Myoung J., Park, Sang H., Bae, Yong-Soo, Kwon, Byoung S.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427336/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427336/

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