Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice

Leishmaniases are a wide spectrum of parasite diseases caused by the infection of different species of Leishmania genus in several mammalian hosts, such as humans and dogs, among others. The induction of antibody responses against some parasite intracellular proteins implicated in different structur...

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Main Authors:	Soto, Manuel, Corvo, Laura, Garde, Esther, Ramírez, Laura, Iniesta, Virginia, Bonay, Pedro, Gómez-Nieto, Carlos, González, Víctor M., Martín, M. Elena, Alonso, Carlos, Coelho, Eduardo A. F., Barral, Aldina, Barral-Netto, Manoel, Iborra, Salvador
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425485/

id	pubmed-4425485
recordtype	oai_dc
spelling	pubmed-44254852015-05-21 Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice Soto, Manuel Corvo, Laura Garde, Esther Ramírez, Laura Iniesta, Virginia Bonay, Pedro Gómez-Nieto, Carlos González, Víctor M. Martín, M. Elena Alonso, Carlos Coelho, Eduardo A. F. Barral, Aldina Barral-Netto, Manoel Iborra, Salvador Research Article Leishmaniases are a wide spectrum of parasite diseases caused by the infection of different species of Leishmania genus in several mammalian hosts, such as humans and dogs, among others. The induction of antibody responses against some parasite intracellular proteins implicated in different structural and functional cellular roles has been associated with parasite survival, infection progression, down-regulation of the cellular immune responses against the parasites and the development of pathology. The data presented in this work show the antigenic nature of the three members of the Leishmania infantum Poly (A) Binding Protein (LiPABP) family in different forms of natural and experimental leishmaniasis. Using a susceptible model of progressive leishmaniasis (BALB/c mice infected with Leishmania major), it was shown that the administration of a LiPABPs based combined genetic vaccine was able to induce a partial protection against the disease. Redirection of the IL-10 mediated responses elicited by the parasite LiPABPs after L. major infection towards an IFN-γ specific production by vaccination was related to protection. The inclusion of the LiPABPs in a protective vaccine formulation against leishmaniasis is discussed. Public Library of Science 2015-05-08 /pmc/articles/PMC4425485/ /pubmed/25955652 http://dx.doi.org/10.1371/journal.pntd.0003751 Text en © 2015 Soto et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Soto, Manuel Corvo, Laura Garde, Esther Ramírez, Laura Iniesta, Virginia Bonay, Pedro Gómez-Nieto, Carlos González, Víctor M. Martín, M. Elena Alonso, Carlos Coelho, Eduardo A. F. Barral, Aldina Barral-Netto, Manoel Iborra, Salvador
spellingShingle	Soto, Manuel Corvo, Laura Garde, Esther Ramírez, Laura Iniesta, Virginia Bonay, Pedro Gómez-Nieto, Carlos González, Víctor M. Martín, M. Elena Alonso, Carlos Coelho, Eduardo A. F. Barral, Aldina Barral-Netto, Manoel Iborra, Salvador Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice
author_facet	Soto, Manuel Corvo, Laura Garde, Esther Ramírez, Laura Iniesta, Virginia Bonay, Pedro Gómez-Nieto, Carlos González, Víctor M. Martín, M. Elena Alonso, Carlos Coelho, Eduardo A. F. Barral, Aldina Barral-Netto, Manoel Iborra, Salvador
author_sort	Soto, Manuel
title	Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice
title_short	Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice
title_full	Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice
title_fullStr	Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice
title_full_unstemmed	Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice
title_sort	coadministration of the three antigenic leishmania infantum poly (a) binding proteins as a dna vaccine induces protection against leishmania major infection in balb/c mice
description	Leishmaniases are a wide spectrum of parasite diseases caused by the infection of different species of Leishmania genus in several mammalian hosts, such as humans and dogs, among others. The induction of antibody responses against some parasite intracellular proteins implicated in different structural and functional cellular roles has been associated with parasite survival, infection progression, down-regulation of the cellular immune responses against the parasites and the development of pathology. The data presented in this work show the antigenic nature of the three members of the Leishmania infantum Poly (A) Binding Protein (LiPABP) family in different forms of natural and experimental leishmaniasis. Using a susceptible model of progressive leishmaniasis (BALB/c mice infected with Leishmania major), it was shown that the administration of a LiPABPs based combined genetic vaccine was able to induce a partial protection against the disease. Redirection of the IL-10 mediated responses elicited by the parasite LiPABPs after L. major infection towards an IFN-γ specific production by vaccination was related to protection. The inclusion of the LiPABPs in a protective vaccine formulation against leishmaniasis is discussed.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425485/
_version_	1613221293230915584

Coadministration of the Three Antigenic Leishmania infantum Poly (A) Binding Proteins as a DNA Vaccine Induces Protection against Leishmania major Infection in BALB/c Mice

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