Combining GWAS and RNA-Seq Approaches for Detection of the Causal Mutation for Hereditary Junctional Epidermolysis Bullosa in Sheep

Combining GWAS and RNA-Seq Approaches for Detection of the Causal Mutation for Hereditary Junctional Epidermolysis Bullosa in Sheep

In this study, we demonstrate the use of a genome-wide association mapping together with RNA-seq in a reduced number of samples, as an efficient approach to detect the causal mutation for a Mendelian disease. Junctional epidermolysis bullosa is a recessive genodermatosis that manifests with neonatal...

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Bibliographic Details
Main Authors: Suárez-Vega, Aroa, Gutiérrez-Gil, Beatriz, Benavides, Julio, Perez, Valentín, Tosser-Klopp, Gwenola, Klopp, Christophe, Keennel, Stephen J., Arranz, Juan José
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425408/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425408/

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