Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive ‘macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors,...

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Bibliographic Details
Main Authors: Papaspyridonos, Marianna, Matei, Irina, Huang, Yujie, do Rosario Andre, Maria, Brazier-Mitouart, Helene, Waite, Janelle C., Chan, April S., Kalter, Julie, Ramos, Ilyssa, Wu, Qi, Williams, Caitlin, Wolchok, Jedd D., Chapman, Paul B., Peinado, Hector, Anandasabapathy, Niroshana, Ocean, Allyson J., Kaplan, Rosandra N., Greenfield, Jeffrey P., Bromberg, Jacqueline, Skokos, Dimitris, Lyden, David
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423225/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423225/

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