A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation

A 69-year-old male was admitted to our hospital due to rapidly progressive glomerulonephritis. A peripheral blood smear showed a marked increase in large granular lymphocytes. Flow cytometry analysis of the blood showed a marked increase in CD3-negative and CD56-positive natural killer (NK) cells. A...

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Main Authors:	Kishi, Tomoya, Ikeda, Yuji, Miyazono, Motoaki, Fukushima, Noriyasu, Aoki, Shigehisa, Sanai, Toru, Sakemi, Takanobu
Format:	Online
Language:	English
Published:	Oxford University Press 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421738/

id	pubmed-4421738
recordtype	oai_dc
spelling	pubmed-44217382015-05-15 A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation Kishi, Tomoya Ikeda, Yuji Miyazono, Motoaki Fukushima, Noriyasu Aoki, Shigehisa Sanai, Toru Sakemi, Takanobu II. Clinical Reports A 69-year-old male was admitted to our hospital due to rapidly progressive glomerulonephritis. A peripheral blood smear showed a marked increase in large granular lymphocytes. Flow cytometry analysis of the blood showed a marked increase in CD3-negative and CD56-positive natural killer (NK) cells. A renal biopsy showed a characteristic pathological pattern that involved endocapillary proliferation, a predominance of mononuclear cells and mesangiolysis. Prednisolone was administered, and the patient’s renal function subsequently improved concomitant with the amelioration of NK cell proliferation. In our case, there was evidence of a strong association between NK cell proliferation and glomerulonephritis. Oxford University Press 2011-10 2011-07-27 /pmc/articles/PMC4421738/ /pubmed/25984176 http://dx.doi.org/10.1093/ndtplus/sfr086 Text en © The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kishi, Tomoya Ikeda, Yuji Miyazono, Motoaki Fukushima, Noriyasu Aoki, Shigehisa Sanai, Toru Sakemi, Takanobu
spellingShingle	Kishi, Tomoya Ikeda, Yuji Miyazono, Motoaki Fukushima, Noriyasu Aoki, Shigehisa Sanai, Toru Sakemi, Takanobu A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
author_facet	Kishi, Tomoya Ikeda, Yuji Miyazono, Motoaki Fukushima, Noriyasu Aoki, Shigehisa Sanai, Toru Sakemi, Takanobu
author_sort	Kishi, Tomoya
title	A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_short	A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_full	A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_fullStr	A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_full_unstemmed	A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
title_sort	case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation
description	A 69-year-old male was admitted to our hospital due to rapidly progressive glomerulonephritis. A peripheral blood smear showed a marked increase in large granular lymphocytes. Flow cytometry analysis of the blood showed a marked increase in CD3-negative and CD56-positive natural killer (NK) cells. A renal biopsy showed a characteristic pathological pattern that involved endocapillary proliferation, a predominance of mononuclear cells and mesangiolysis. Prednisolone was administered, and the patient’s renal function subsequently improved concomitant with the amelioration of NK cell proliferation. In our case, there was evidence of a strong association between NK cell proliferation and glomerulonephritis.
publisher	Oxford University Press
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421738/
_version_	1613219941469650944

A case of endocapillary glomerulonephritis associated with peripheral blood natural killer cell proliferation

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