High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection
Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Oxford University Press
2009
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421192/ |
| Summary: | Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis of polyomavirus nephropathy (PVN). BK virus (BKV) DNA was identified in urine and serum by PCR. The diffuse strong staining of SV40 T-antigen and p53 within both the in situ and invasive carcinoma suggest that BKV may play a role in the oncogenic pathway in this clinical setting. |
|---|