Regulating the Coordination State of a Heme Protein by a Designed Distal Hydrogen-Bonding Network
Heme coordination state determines the functional diversity of heme proteins. Using myoglobin as a model protein, we designed a distal hydrogen-bonding network by introducing both distal glutamic acid (Glu29) and histidine (His43) residues and regulated the heme into a bis-His coordination state wit...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
BlackWell Publishing Ltd
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420578/ |