RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact
The regulation of RNA decay is now widely recognized as having a central role in bacterial adaption to environmental stress. Here we present an overview on the diversity of ribonucleases (RNases) and their impact at the posttranscriptional level in the human pathogen Staphylococcus aureus. RNases in...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419217/ |
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pubmed-4419217 |
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pubmed-44192172015-05-14 RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact Bonnin, Rémy A. Bouloc, Philippe Review Article The regulation of RNA decay is now widely recognized as having a central role in bacterial adaption to environmental stress. Here we present an overview on the diversity of ribonucleases (RNases) and their impact at the posttranscriptional level in the human pathogen Staphylococcus aureus. RNases in prokaryotes have been mainly studied in the two model organisms Escherichia coli and Bacillus subtilis. Based on identified RNases in these two models, putative orthologs have been identified in S. aureus. The main staphylococcal RNases involved in the processing and degradation of the bulk RNA are (i) endonucleases RNase III and RNase Y and (ii) exonucleases RNase J1/J2 and PNPase, having 5′ to 3′ and 3′ to 5′ activities, respectively. The diversity and potential roles of each RNase and of Hfq and RppH are discussed in the context of recent studies, some of which are based on next-generation sequencing technology. Hindawi Publishing Corporation 2015 2015-04-21 /pmc/articles/PMC4419217/ /pubmed/25977913 http://dx.doi.org/10.1155/2015/395753 Text en Copyright © 2015 R. A. Bonnin and P. Bouloc. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Bonnin, Rémy A. Bouloc, Philippe |
| spellingShingle |
Bonnin, Rémy A. Bouloc, Philippe RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact |
| author_facet |
Bonnin, Rémy A. Bouloc, Philippe |
| author_sort |
Bonnin, Rémy A. |
| title |
RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact |
| title_short |
RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact |
| title_full |
RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact |
| title_fullStr |
RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact |
| title_full_unstemmed |
RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact |
| title_sort |
rna degradation in staphylococcus aureus: diversity of ribonucleases and their impact |
| description |
The regulation of RNA decay is now widely recognized as having a central role in bacterial adaption to environmental stress. Here we present an overview on the diversity of ribonucleases (RNases) and their impact at the posttranscriptional level in the human pathogen Staphylococcus aureus. RNases in prokaryotes have been mainly studied in the two model organisms Escherichia coli and Bacillus subtilis. Based on identified RNases in these two models, putative orthologs have been identified in S. aureus. The main staphylococcal RNases involved in the processing and degradation of the bulk RNA are (i) endonucleases RNase III and RNase Y and (ii) exonucleases RNase J1/J2 and PNPase, having 5′ to 3′ and 3′ to 5′ activities, respectively. The diversity and potential roles of each RNase and of Hfq and RppH are discussed in the context of recent studies, some of which are based on next-generation sequencing technology. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419217/ |
| _version_ |
1613218953779216384 |