Deficiency for the Cysteine Protease Cathepsin L Impairs Myc-Induced Tumorigenesis in a Mouse Model of Pancreatic Neuroendocrine Cancer

Deficiency for the Cysteine Protease Cathepsin L Impairs Myc-Induced Tumorigenesis in a Mouse Model of Pancreatic Neuroendocrine Cancer

Motivated by the recent implication of cysteine protease cathepsin L as a potential target for anti-cancer drug development, we used a conditional MycERTAM;Bcl-xL model of pancreatic neuroendocrine tumorigenesis (PNET) to assess the role of cathepsin L in Myc-induced tumor progression. By employing...

Full description

Bibliographic Details
Main Authors: Brindle, Nicola R., Joyce, Johanna A., Rostker, Fanya, Lawlor, Elizabeth R., Swigart-Brown, Lamorna, Evan, Gerard, Hanahan, Douglas, Shchors, Ksenya
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415914/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415914/

Similar Items