Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed

The purpose of this study was to determine: (1) whether damage to liver and skeletal muscles occurs during a 100 km run; (2) whether the metabolic response to extreme exertion is related to the age or running speed of the participant; (3) whether it is possible to determine the optimal running speed...

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Main Authors:	Jastrzębski, Zbigniew, Żychowska, Małgorzata, Radzimiński, Łukasz, Konieczna, Anna, Kortas, Jakub
Format:	Online
Language:	English
Published:	Akademia Wychowania Fizycznego w Katowicach 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415847/

id	pubmed-4415847
recordtype	oai_dc
spelling	pubmed-44158472015-05-11 Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed Jastrzębski, Zbigniew Żychowska, Małgorzata Radzimiński, Łukasz Konieczna, Anna Kortas, Jakub Research Article The purpose of this study was to determine: (1) whether damage to liver and skeletal muscles occurs during a 100 km run; (2) whether the metabolic response to extreme exertion is related to the age or running speed of the participant; (3) whether it is possible to determine the optimal running speed and distance for long-distance runners’ health by examining biochemical parameters in venous blood. Fourteen experienced male amateur ultra-marathon runners, divided into two age groups, took part in a 100 km run. Blood samples for liver and skeletal muscle damage indexes were collected from the ulnar vein just before the run, after 25, 50, 75 and 100 km, and 24 hours after termination of the run. A considerable increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was observed with the distance covered (p < 0.05), which continued during recovery. An increase in the mean values of lactate dehydrogenase (LDH), creatine kinase (CK) and C-reactive protein (CRP) (p < 0.05) was observed with each sequential course. The biggest differences between the age groups were found for the activity of liver enzymes and LDH after completing 75 km as well as after 24 hours of recovery. It can be concluded that the response to extreme exertion deteriorates with age in terms of the active movement apparatus. Akademia Wychowania Fizycznego w Katowicach 2015-04-07 /pmc/articles/PMC4415847/ /pubmed/25964813 http://dx.doi.org/10.1515/hukin-2015-0010 Text en © Editorial Committee of Journal of Human Kinetics This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Jastrzębski, Zbigniew Żychowska, Małgorzata Radzimiński, Łukasz Konieczna, Anna Kortas, Jakub
spellingShingle	Jastrzębski, Zbigniew Żychowska, Małgorzata Radzimiński, Łukasz Konieczna, Anna Kortas, Jakub Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed
author_facet	Jastrzębski, Zbigniew Żychowska, Małgorzata Radzimiński, Łukasz Konieczna, Anna Kortas, Jakub
author_sort	Jastrzębski, Zbigniew
title	Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed
title_short	Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed
title_full	Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed
title_fullStr	Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed
title_full_unstemmed	Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed
title_sort	damage to liver and skeletal muscles in marathon runners during a 100 km run with regard to age and running speed
description	The purpose of this study was to determine: (1) whether damage to liver and skeletal muscles occurs during a 100 km run; (2) whether the metabolic response to extreme exertion is related to the age or running speed of the participant; (3) whether it is possible to determine the optimal running speed and distance for long-distance runners’ health by examining biochemical parameters in venous blood. Fourteen experienced male amateur ultra-marathon runners, divided into two age groups, took part in a 100 km run. Blood samples for liver and skeletal muscle damage indexes were collected from the ulnar vein just before the run, after 25, 50, 75 and 100 km, and 24 hours after termination of the run. A considerable increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was observed with the distance covered (p < 0.05), which continued during recovery. An increase in the mean values of lactate dehydrogenase (LDH), creatine kinase (CK) and C-reactive protein (CRP) (p < 0.05) was observed with each sequential course. The biggest differences between the age groups were found for the activity of liver enzymes and LDH after completing 75 km as well as after 24 hours of recovery. It can be concluded that the response to extreme exertion deteriorates with age in terms of the active movement apparatus.
publisher	Akademia Wychowania Fizycznego w Katowicach
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415847/
_version_	1613217947838316544

Damage to Liver and Skeletal Muscles in Marathon Runners During a 100 km Run With Regard to Age and Running Speed

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