Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex
When choosing actions, we can act decisively, vacillate, or suffer momentary indecision. Studying how individual decisions unfold requires moment-by-moment readouts of brain state. Here we provide such a view from dorsal premotor and primary motor cortex. Two monkeys performed a novel decision task...
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| Format: | Online |
| Language: | English |
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eLife Sciences Publications, Ltd
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415122/ |
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pubmed-4415122 |
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pubmed-44151222015-05-06 Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex Kaufman, Matthew T Churchland, Mark M Ryu, Stephen I Shenoy, Krishna V Neuroscience When choosing actions, we can act decisively, vacillate, or suffer momentary indecision. Studying how individual decisions unfold requires moment-by-moment readouts of brain state. Here we provide such a view from dorsal premotor and primary motor cortex. Two monkeys performed a novel decision task while we recorded from many neurons simultaneously. We found that a decoder trained using ‘forced choices’ (one target viable) was highly reliable when applied to ‘free choices’. However, during free choices internal events formed three categories. Typically, neural activity was consistent with rapid, unwavering choices. Sometimes, though, we observed presumed ‘changes of mind’: the neural state initially reflected one choice before changing to reflect the final choice. Finally, we observed momentary ‘indecision’: delay forming any clear motor plan. Further, moments of neural indecision accompanied moments of behavioral indecision. Together, these results reveal the rich and diverse set of internal events long suspected to occur during free choice. eLife Sciences Publications, Ltd 2015-05-05 /pmc/articles/PMC4415122/ /pubmed/25942352 http://dx.doi.org/10.7554/eLife.04677 Text en © 2015, Kaufman et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kaufman, Matthew T Churchland, Mark M Ryu, Stephen I Shenoy, Krishna V |
| spellingShingle |
Kaufman, Matthew T Churchland, Mark M Ryu, Stephen I Shenoy, Krishna V Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex |
| author_facet |
Kaufman, Matthew T Churchland, Mark M Ryu, Stephen I Shenoy, Krishna V |
| author_sort |
Kaufman, Matthew T |
| title |
Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex |
| title_short |
Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex |
| title_full |
Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex |
| title_fullStr |
Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex |
| title_full_unstemmed |
Vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex |
| title_sort |
vacillation, indecision and hesitation in moment-by-moment decoding of monkey motor cortex |
| description |
When choosing actions, we can act decisively, vacillate, or suffer momentary indecision. Studying how individual decisions unfold requires moment-by-moment readouts of brain state. Here we provide such a view from dorsal premotor and primary motor cortex. Two monkeys performed a novel decision task while we recorded from many neurons simultaneously. We found that a decoder trained using ‘forced choices’ (one target viable) was highly reliable when applied to ‘free choices’. However, during free choices internal events formed three categories. Typically, neural activity was consistent with rapid, unwavering choices. Sometimes, though, we observed presumed ‘changes of mind’: the neural state initially reflected one choice before changing to reflect the final choice. Finally, we observed momentary ‘indecision’: delay forming any clear motor plan. Further, moments of neural indecision accompanied moments of behavioral indecision. Together, these results reveal the rich and diverse set of internal events long suspected to occur during free choice. |
| publisher |
eLife Sciences Publications, Ltd |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415122/ |
| _version_ |
1613217656363548672 |