Aging of Skeletal Muscle Fibers
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilit...
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Korean Academy of Rehabilitation Medicine
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414960/ |
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pubmed-44149602015-04-30 Aging of Skeletal Muscle Fibers Miljkovic, Natasa Lim, Jae-Young Miljkovic, Iva Frontera, Walter R. Review Article Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs. Korean Academy of Rehabilitation Medicine 2015-04 2015-04-24 /pmc/articles/PMC4414960/ /pubmed/25932410 http://dx.doi.org/10.5535/arm.2015.39.2.155 Text en Copyright © 2015 by Korean Academy of Rehabilitation Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Miljkovic, Natasa Lim, Jae-Young Miljkovic, Iva Frontera, Walter R. |
| spellingShingle |
Miljkovic, Natasa Lim, Jae-Young Miljkovic, Iva Frontera, Walter R. Aging of Skeletal Muscle Fibers |
| author_facet |
Miljkovic, Natasa Lim, Jae-Young Miljkovic, Iva Frontera, Walter R. |
| author_sort |
Miljkovic, Natasa |
| title |
Aging of Skeletal Muscle Fibers |
| title_short |
Aging of Skeletal Muscle Fibers |
| title_full |
Aging of Skeletal Muscle Fibers |
| title_fullStr |
Aging of Skeletal Muscle Fibers |
| title_full_unstemmed |
Aging of Skeletal Muscle Fibers |
| title_sort |
aging of skeletal muscle fibers |
| description |
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs. |
| publisher |
Korean Academy of Rehabilitation Medicine |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414960/ |
| _version_ |
1613217608488714240 |