Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology
•Proteomics was used to identify the cellular interactome of PRRSV N protein.•The interactome included translation factors and PARP-1.•Inhibition of PARP-1 by the small molecule 3-AB resulted in a decrease in virus infection.•Sustained treatment of PRRSV infected cells with 3-AB suggested resistance...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Scientific Pub. Co
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414928/ |