Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease
Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal inflammation, inflammatory bowel disease (IBD) patients, and tumor tissues. Howev...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Korean Association for the Study of Intestinal Diseases
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414751/ |
| id |
pubmed-4414751 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-44147512015-04-30 Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease Kim, Yeon-Jeong Chang, Sun-Young Ko, Hyun-Jeong Review Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal inflammation, inflammatory bowel disease (IBD) patients, and tumor tissues. However, the roles of MDSCs in IBD are not yet well understood, and there are controversies regarding their immunosuppressive functions in IBD. In addition, recent studies have suggested that endoplasmic reticulum (ER) stress in intestinal epithelial cells, especially in Paneth cells, is closely associated with the induction of IBD. However, the ER stress in MDSCs accumulated in the inflamed tissues of IBD patients is not yet fully understood. In the current review, we discuss the presence of accumulated MDSCs in the intestines of IBD patients, and further speculate on their physiological roles in the inflammatory condition with interleukin 17-producing cells, including Th17 cells. In particular, we will discuss the divergent functions of MDSCs in ER stressed intestinal environments, including their pro-inflammatory or immunosuppressive roles, based on the consideration of unfolded protein responses initiated in intestinal epithelial cells by ER stress. Korean Association for the Study of Intestinal Diseases 2015-04 2015-04-27 /pmc/articles/PMC4414751/ /pubmed/25931994 http://dx.doi.org/10.5217/ir.2015.13.2.105 Text en © Copyright 2015. Korean Association for the Study of Intestinal Diseases. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kim, Yeon-Jeong Chang, Sun-Young Ko, Hyun-Jeong |
| spellingShingle |
Kim, Yeon-Jeong Chang, Sun-Young Ko, Hyun-Jeong Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease |
| author_facet |
Kim, Yeon-Jeong Chang, Sun-Young Ko, Hyun-Jeong |
| author_sort |
Kim, Yeon-Jeong |
| title |
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease |
| title_short |
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease |
| title_full |
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease |
| title_fullStr |
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease |
| title_full_unstemmed |
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease |
| title_sort |
myeloid-derived suppressor cells in inflammatory bowel disease |
| description |
Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal inflammation, inflammatory bowel disease (IBD) patients, and tumor tissues. However, the roles of MDSCs in IBD are not yet well understood, and there are controversies regarding their immunosuppressive functions in IBD. In addition, recent studies have suggested that endoplasmic reticulum (ER) stress in intestinal epithelial cells, especially in Paneth cells, is closely associated with the induction of IBD. However, the ER stress in MDSCs accumulated in the inflamed tissues of IBD patients is not yet fully understood. In the current review, we discuss the presence of accumulated MDSCs in the intestines of IBD patients, and further speculate on their physiological roles in the inflammatory condition with interleukin 17-producing cells, including Th17 cells. In particular, we will discuss the divergent functions of MDSCs in ER stressed intestinal environments, including their pro-inflammatory or immunosuppressive roles, based on the consideration of unfolded protein responses initiated in intestinal epithelial cells by ER stress. |
| publisher |
Korean Association for the Study of Intestinal Diseases |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414751/ |
| _version_ |
1613217550521335808 |