Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Osteosarcomas, the most common malignant bone tumors, show a potent capacity for local invasion and pulmonary metastasis. Resveratrol (RESV), a phytochemical, exhibits multiple tumor-suppressing activities and has been tested in clinical trials. However, the antitumor activities of RESV in osteosarc...

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Bibliographic Details
Main Authors: Yang, Shun-Fa, Lee, Wei-Jiunn, Tan, Peng, Tang, Chih-Hsin, Hsiao, Michael, Hsieh, Feng-Koo, Chien, Ming-Hsien
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413614/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413614/

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