Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

Chrysin (5, 7- dihydroxyflavone) is a flavonoid with several pharmacological properties that include antioxidant, anti-inflammatory and antiapoptotic activities. in this work, we investigated some effects of three graded oral doses of chrysin (10, 50 and 250 mg/kg) on kidney structure and function i...

Full description

Bibliographic Details
Main Authors:	Ali, Badreldin H., Adham, Sirin A., Al Za’abi, Mohammed, Waly, Mostafa I., Yasin, Javed, Nemmar, Abderrahim, Schupp, Nicole
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409384/

id	pubmed-4409384
recordtype	oai_dc
spelling	pubmed-44093842015-05-12 Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats Ali, Badreldin H. Adham, Sirin A. Al Za’abi, Mohammed Waly, Mostafa I. Yasin, Javed Nemmar, Abderrahim Schupp, Nicole Research Article Chrysin (5, 7- dihydroxyflavone) is a flavonoid with several pharmacological properties that include antioxidant, anti-inflammatory and antiapoptotic activities. in this work, we investigated some effects of three graded oral doses of chrysin (10, 50 and 250 mg/kg) on kidney structure and function in rats with experimental chronic renal disease (CKD) induced by adenine (0.25% w/w in feed for 35 days), which is known to involve inflammation and oxidative stress. Using several indices in plasma, urine and kidney homogenates, adenine was found to impair kidney function as it lowered creatinine clearance and increased plasma concentrations of creatinine, urea, neutrophil gelatinase-associated lipocalin and N-Acetyl-beta-D-glucosaminidase activity. Furthermore, it raised plasma concentrations of the uremic toxin indoxyl sulfate, some inflammatory cytokines and urinary albumin concentration. Renal morphology was severely damaged and histopathological markers of inflammation and fibrosis were especially increased. In renal homogenates, antioxidant indices, including superoxide dismutase and catalase activities, total antioxidant capacity and reduced glutathione were all adversely affected. Most of these adenine – induced actions were moderately and dose -dependently mitigated by chrysin, especially at the highest dose. Chrysin did not cause any overt adverse effect on the treated rats. The results suggest that different doses of chrysin produce variable salutary effects against adenine-induced CKD in rats, and that, pending further pharmacological and toxicological studies, its usability as a possible ameliorative agent in human CKD should be considered. Public Library of Science 2015-04-24 /pmc/articles/PMC4409384/ /pubmed/25909514 http://dx.doi.org/10.1371/journal.pone.0125285 Text en © 2015 Ali et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ali, Badreldin H. Adham, Sirin A. Al Za’abi, Mohammed Waly, Mostafa I. Yasin, Javed Nemmar, Abderrahim Schupp, Nicole
spellingShingle	Ali, Badreldin H. Adham, Sirin A. Al Za’abi, Mohammed Waly, Mostafa I. Yasin, Javed Nemmar, Abderrahim Schupp, Nicole Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats
author_facet	Ali, Badreldin H. Adham, Sirin A. Al Za’abi, Mohammed Waly, Mostafa I. Yasin, Javed Nemmar, Abderrahim Schupp, Nicole
author_sort	Ali, Badreldin H.
title	Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats
title_short	Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats
title_full	Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats
title_fullStr	Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats
title_full_unstemmed	Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats
title_sort	ameliorative effect of chrysin on adenine-induced chronic kidney disease in rats
description	Chrysin (5, 7- dihydroxyflavone) is a flavonoid with several pharmacological properties that include antioxidant, anti-inflammatory and antiapoptotic activities. in this work, we investigated some effects of three graded oral doses of chrysin (10, 50 and 250 mg/kg) on kidney structure and function in rats with experimental chronic renal disease (CKD) induced by adenine (0.25% w/w in feed for 35 days), which is known to involve inflammation and oxidative stress. Using several indices in plasma, urine and kidney homogenates, adenine was found to impair kidney function as it lowered creatinine clearance and increased plasma concentrations of creatinine, urea, neutrophil gelatinase-associated lipocalin and N-Acetyl-beta-D-glucosaminidase activity. Furthermore, it raised plasma concentrations of the uremic toxin indoxyl sulfate, some inflammatory cytokines and urinary albumin concentration. Renal morphology was severely damaged and histopathological markers of inflammation and fibrosis were especially increased. In renal homogenates, antioxidant indices, including superoxide dismutase and catalase activities, total antioxidant capacity and reduced glutathione were all adversely affected. Most of these adenine – induced actions were moderately and dose -dependently mitigated by chrysin, especially at the highest dose. Chrysin did not cause any overt adverse effect on the treated rats. The results suggest that different doses of chrysin produce variable salutary effects against adenine-induced CKD in rats, and that, pending further pharmacological and toxicological studies, its usability as a possible ameliorative agent in human CKD should be considered.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409384/
_version_	1613215556728520704

Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

Similar Items