In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells

In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells

In aged mice, new B-cell development is diminished and the antibody repertoire becomes more autoreactive. Our studies suggest that (i) apoptosis contributes to reduced B lymphopoiesis in old age and preferentially eliminates those B-cell precursors with higher levels of the surrogate light chain (SL...

Full description

Bibliographic Details
Main Authors: Ratliff, Michelle, Alter, Sarah, McAvoy, Kelly, Frasca, Daniela, Wright, Jacqueline A, Zinkel, Sandra S, Khan, Wasif N, Blomberg, Bonnie B, Riley, Richard L
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406667/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406667/

Similar Items