Type I Interferon-Mediated Skewing of the Serotonin Synthesis Is Associated with Severe Disease in Systemic Lupus Erythematosus

Type I Interferon-Mediated Skewing of the Serotonin Synthesis Is Associated with Severe Disease in Systemic Lupus Erythematosus

Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study...

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Bibliographic Details
Main Authors: Lood, Christian, Tydén, Helena, Gullstrand, Birgitta, Klint, Cecilia, Wenglén, Christina, Nielsen, Christoffer T., Heegaard, Niels H. H., Jönsen, Andreas, Kahn, Robin, Bengtsson, Anders A.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405357/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405357/

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