Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine

Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine

Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed...

Full description

Bibliographic Details
Main Authors: Saengsai, Jutamas, Kongtunjanphuk, Sumonthip, Yoswatthana, Nuttawan, Kummalue, Tanawan, Jiratchariyakul, Weena
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405293/
id pubmed-4405293
recordtype oai_dc
spelling pubmed-44052932015-05-05 Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine Saengsai, Jutamas Kongtunjanphuk, Sumonthip Yoswatthana, Nuttawan Kummalue, Tanawan Jiratchariyakul, Weena Research Article Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED50) of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells. Hindawi Publishing Corporation 2015 2015-04-07 /pmc/articles/PMC4405293/ /pubmed/25945113 http://dx.doi.org/10.1155/2015/823178 Text en Copyright © 2015 Jutamas Saengsai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Saengsai, Jutamas
Kongtunjanphuk, Sumonthip
Yoswatthana, Nuttawan
Kummalue, Tanawan
Jiratchariyakul, Weena
spellingShingle Saengsai, Jutamas
Kongtunjanphuk, Sumonthip
Yoswatthana, Nuttawan
Kummalue, Tanawan
Jiratchariyakul, Weena
Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
author_facet Saengsai, Jutamas
Kongtunjanphuk, Sumonthip
Yoswatthana, Nuttawan
Kummalue, Tanawan
Jiratchariyakul, Weena
author_sort Saengsai, Jutamas
title Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_short Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_full Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_fullStr Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_full_unstemmed Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine
title_sort antibacterial and antiproliferative activities of plumericin, an iridoid isolated from momordica charantia vine
description Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED50) of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.
publisher Hindawi Publishing Corporation
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405293/
_version_ 1613214105443762176

Similar Items