Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18

Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18

Positron emission tomography (PET) is unique in that it allows quantification of biochemical processes in vivo, but difficulties with preparing suitably labelled radiotracers limit its scientific and diagnostic applications. Aromatic [18F]fluorination of drug-like small molecules is particularly cha...

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Bibliographic Details
Main Authors: Sander, Kerstin, Gendron, Thibault, Yiannaki, Elena, Cybulska, Klaudia, Kalber, Tammy L., Lythgoe, Mark F., Årstad, Erik
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404714/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404714/

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