Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the secretion of IFN-I from pDCs. BDCA2 is a pDC-specific receptor th...

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Bibliographic Details
Main Authors: Pellerin, Alex, Otero, Karel, Czerkowicz, Julie M, Kerns, Hannah M, Shapiro, Renée I, Ranger, Ann M, Otipoby, Kevin L, Taylor, Frederick R, Cameron, Thomas O, Viney, Joanne L, Rabah, Dania
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403047/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403047/

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