Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study

The occlusion of dentinal tubules is an effective method to alleviate the symptoms caused by dentin hypersensitivity, a significant health problem in dentistry and daily life. The in situ mineralization within dentinal tubules is a promising treatment for dentin hypersensitivity as it induces the fo...

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Main Authors:	Wang, Tianda, Yang, Sheng, Wang, Lei, Feng, Hailan
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401684/

id	pubmed-4401684
recordtype	oai_dc
spelling	pubmed-44016842015-04-21 Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study Wang, Tianda Yang, Sheng Wang, Lei Feng, Hailan Research Article The occlusion of dentinal tubules is an effective method to alleviate the symptoms caused by dentin hypersensitivity, a significant health problem in dentistry and daily life. The in situ mineralization within dentinal tubules is a promising treatment for dentin hypersensitivity as it induces the formation of mineral on the sensitive regions and occludes the dentinal tubules. This study was carried out to evaluate the in vitro effect of a whole generation poly(amidoamine) (PAMAM) dendrimer (G3.0) on dentinal tubule occlusion by inducing mineralization within dentinal tubules. Dentin discs were treated with PAMAM dendrimers using two methods, followed by the in vitro characterization using Attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM) and Energy-Dispersive X-ray Spectroscopy (EDS). These results showed that G3.0 PAMAM dendrimers coated on dentin surface and infiltrated in dentinal tubules could induce hydroxyapatite formation and resulted in effective dentinal tubule occlusion. Moreover, crosslinked PAMAM dendrimers could induce the remineralization of demineralized dentin and thus had the potential in dentinal tubule occlusion. In this in vitro study, dentinal tubules occlusion could be achieved by using PAMAM dendrimers. This could lead to the development of a new therapeutic technique for the treatment of dentin hypersensitivity. Public Library of Science 2015-04-17 /pmc/articles/PMC4401684/ /pubmed/25885090 http://dx.doi.org/10.1371/journal.pone.0124735 Text en © 2015 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Tianda Yang, Sheng Wang, Lei Feng, Hailan
spellingShingle	Wang, Tianda Yang, Sheng Wang, Lei Feng, Hailan Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study
author_facet	Wang, Tianda Yang, Sheng Wang, Lei Feng, Hailan
author_sort	Wang, Tianda
title	Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study
title_short	Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study
title_full	Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study
title_fullStr	Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study
title_full_unstemmed	Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study
title_sort	use of poly (amidoamine) dendrimer for dentinal tubule occlusion: a preliminary study
description	The occlusion of dentinal tubules is an effective method to alleviate the symptoms caused by dentin hypersensitivity, a significant health problem in dentistry and daily life. The in situ mineralization within dentinal tubules is a promising treatment for dentin hypersensitivity as it induces the formation of mineral on the sensitive regions and occludes the dentinal tubules. This study was carried out to evaluate the in vitro effect of a whole generation poly(amidoamine) (PAMAM) dendrimer (G3.0) on dentinal tubule occlusion by inducing mineralization within dentinal tubules. Dentin discs were treated with PAMAM dendrimers using two methods, followed by the in vitro characterization using Attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM) and Energy-Dispersive X-ray Spectroscopy (EDS). These results showed that G3.0 PAMAM dendrimers coated on dentin surface and infiltrated in dentinal tubules could induce hydroxyapatite formation and resulted in effective dentinal tubule occlusion. Moreover, crosslinked PAMAM dendrimers could induce the remineralization of demineralized dentin and thus had the potential in dentinal tubule occlusion. In this in vitro study, dentinal tubules occlusion could be achieved by using PAMAM dendrimers. This could lead to the development of a new therapeutic technique for the treatment of dentin hypersensitivity.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401684/
_version_	1613212998772457472

Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study

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