Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomos...

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Bibliographic Details
Main Authors: Franco, Claudio A., Jones, Martin L., Bernabeu, Miguel O., Geudens, Ilse, Mathivet, Thomas, Rosa, Andre, Lopes, Felicia M., Lima, Aida P., Ragab, Anan, Collins, Russell T., Phng, Li-Kun, Coveney, Peter V., Gerhardt, Holger
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401640/