The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol

The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol

•Interaction between Fasciola hepatica and VTEC O157 in cattle.•Simulations that calculate statistical power for association between two pathogens.•Simulation parameters for a study constrained by a pre-determined design.•Augmenting a prospective study on VTEC O157 prevalence with a co-infection stu...

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Main Authors: Hickey, Graeme L., Diggle, Peter J., McNeilly, Tom N., Tongue, Sue C., Chase-Topping, Margo E., Williams, Diana J.L.
Format: Online
Language:English
Published: Elsevier Scientific Publishing 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401447/
id pubmed-4401447
recordtype oai_dc
spelling pubmed-44014472015-05-01 The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol Hickey, Graeme L. Diggle, Peter J. McNeilly, Tom N. Tongue, Sue C. Chase-Topping, Margo E. Williams, Diana J.L. Article •Interaction between Fasciola hepatica and VTEC O157 in cattle.•Simulations that calculate statistical power for association between two pathogens.•Simulation parameters for a study constrained by a pre-determined design.•Augmenting a prospective study on VTEC O157 prevalence with a co-infection study.•Results show an 87% power to detect an odds ratio of 2. Elsevier Scientific Publishing 2015-05-01 /pmc/articles/PMC4401447/ /pubmed/25779556 http://dx.doi.org/10.1016/j.prevetmed.2015.02.022 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Hickey, Graeme L.
Diggle, Peter J.
McNeilly, Tom N.
Tongue, Sue C.
Chase-Topping, Margo E.
Williams, Diana J.L.
spellingShingle Hickey, Graeme L.
Diggle, Peter J.
McNeilly, Tom N.
Tongue, Sue C.
Chase-Topping, Margo E.
Williams, Diana J.L.
The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol
author_facet Hickey, Graeme L.
Diggle, Peter J.
McNeilly, Tom N.
Tongue, Sue C.
Chase-Topping, Margo E.
Williams, Diana J.L.
author_sort Hickey, Graeme L.
title The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol
title_short The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol
title_full The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol
title_fullStr The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol
title_full_unstemmed The feasibility of testing whether Fasciola hepatica is associated with increased risk of verocytotoxin producing Escherichia coli O157 from an existing study protocol
title_sort feasibility of testing whether fasciola hepatica is associated with increased risk of verocytotoxin producing escherichia coli o157 from an existing study protocol
description •Interaction between Fasciola hepatica and VTEC O157 in cattle.•Simulations that calculate statistical power for association between two pathogens.•Simulation parameters for a study constrained by a pre-determined design.•Augmenting a prospective study on VTEC O157 prevalence with a co-infection study.•Results show an 87% power to detect an odds ratio of 2.
publisher Elsevier Scientific Publishing
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401447/
_version_ 1613212929070465024

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